abstract：:CD4(+) T cells specific for immunologic non-self determinants on self-IgG, idiotopes (Id), can be raised from cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS). To test if Id-specific CD4(+) T cells have the potential to destroy oligodendrocytes (ODCs), we analyzed their ability to induce ap...

journal_title：Journal of autoimmunity

authors： Hestvik AL,Skorstad G,Vartdal F,Holmøy T

更新日期：2009-03-01 00:00:00

abstract：:Catastrophic antiphospholipid (Asherson's) syndrome (cAPS) was described in the past as a severe variant of the antiphospholipid syndrome (APS). Currently growing evidence suggests it is a unique condition. This statement is based on several clinical and physiopathological features that although not well understood de...

journal_title：Journal of autoimmunity

authors： Ortega-Hernandez OD,Agmon-Levin N,Blank M,Asherson RA,Shoenfeld Y

更新日期：2009-02-01 00:00:00

abstract：:Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...

journal_title：Journal of autoimmunity

authors： Liu Z,Sui W,Zhao M,Li Z,Li N,Thresher R,Giudice GJ,Fairley JA,Sitaru C,Zillikens D,Ning G,Marinkovich MP,Diaz LA

更新日期：2008-12-01 00:00:00

abstract：:CD4(+) IFN-gamma-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoi...

journal_title：Journal of autoimmunity

authors： Dardalhon V,Korn T,Kuchroo VK,Anderson AC

更新日期：2008-11-01 00:00:00

abstract：:Solute carrier family 11 member a1 (SLC11A1) exerts pleiotropic effects on macrophage function. Expression of SLC11A1 is regulated by a (GT)(n) microsatellite promoter repeat polymorphism of which nine alleles have been described. Enhanced activation of macrophages, associated with increased expression from allele 3, ...

journal_title：Journal of autoimmunity

authors： O'Brien BA,Archer NS,Simpson AM,Torpy FR,Nassif NT

更新日期：2008-08-01 00:00:00

abstract：:Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies. RDP58 is a novel d-amino acid decapeptide with potent immunosuppressive activity. In this study, we investi...

journal_title：Journal of autoimmunity

authors： Liu W,Deyoung BR,Chen X,Evanoff DP,Luo Y

更新日期：2008-06-01 00:00:00

abstract：:HLA-DQB1 is widely considered to be the major histocompatibility complex (MHC) susceptibility gene for type 1 diabetes (T1D). However, since inheritance of the gene in T1D is recessive, the presence of the protective HLA-DQB1 0602 allele with normal nucleotide sequence in some patients raises the question of whether H...

journal_title：Journal of autoimmunity

authors： Husain Z,Kelly MA,Eisenbarth GS,Pugliese A,Awdeh ZL,Larsen CE,Alper CA

更新日期：2008-06-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (HCT) is an increasingly widely used treatment modality in hematological malignancies. Alloreactivity mediated by donor T cells (and, in some settings, by donor natural killer cells) can produce durable immunologic control or eradication of residual malignancy after alloge...

journal_title：Journal of autoimmunity

authors： Rezvani AR,Storb RF

更新日期：2008-05-01 00:00:00

abstract：:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

journal_title：Journal of autoimmunity

authors： Sonoda Y

更新日期：2008-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered to be a promising platform for cell and gene therapy for a variety of diseases. First, in the field of hematopoietic stem cell transplantation, there are two applications of MSCs: 1) the improvement of stem cell engrafting and the acceleration of hematopoietic reconstitutio...

journal_title：Journal of autoimmunity

authors： Ozawa K,Sato K,Oh I,Ozaki K,Uchibori R,Obara Y,Kikuchi Y,Ito T,Okada T,Urabe M,Mizukami H,Kume A

更新日期：2008-05-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss in the presence of antiphospholipid antibodies (aPL), mainly anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant. However, similar to systemic lupus erythematosus, APS is also characterized by multiple other autoantibodies...

journal_title：Journal of autoimmunity

authors： Shoenfeld Y,Twig G,Katz U,Sherer Y

更新日期：2008-02-01 00:00:00

abstract：:Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4(+) T cells were stimulated with plate-bound anti-CD3 and cultured for 12 days after which they ...

journal_title：Journal of autoimmunity

authors： Abraham M,Karni A,Dembinsky A,Miller A,Gandhi R,Anderson D,Weiner HL

更新日期：2008-02-01 00:00:00

abstract：:TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha early in life experience an acceleration in disease onset while TNF-alpha administered to adult NOD mice are ...

journal_title：Journal of autoimmunity

authors： Middlebrook AJ,Lebsack T,DeLuca D

更新日期：2007-09-01 00:00:00

abstract：:Beta(2)-glycoprotein I (beta(2)GPI) is known as a major autoantigen for antiphospholipid antibodies. Our recent data show that binding of beta(2)GPI to oxidized low-density lipoprotein (oxLDL) or to liposomes containing anionic phospholipid(s) may facilitate the presentation of beta(2)GPI's epitope by macrophages/dend...

journal_title：Journal of autoimmunity

authors： Kajiwara T,Yasuda T,Matsuura E

更新日期：2007-09-01 00:00:00

abstract：:Immuno-regulatory defects, including a reduction in the number and function of regulatory T cells, play an important role in the development of autoimmune diabetes in both humans and non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 into antigen non-specific polyclonal and anti...

journal_title：Journal of autoimmunity

authors： Peng J,Dicker B,Du W,Tang F,Nguyen P,Geiger T,Wong FS,Wen L

更新日期：2007-06-01 00:00:00

abstract：:Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

journal_title：Journal of autoimmunity

authors： Gleicher N,Barad DH

更新日期：2007-02-01 00:00:00

abstract：:The probability that epitope spreading occurs in multiple sclerosis (MS) and the fact that patients have been shown to respond to multiple myelin epitopes concurrently makes the use of peptide-specific tolerance therapies targeting single epitopes problematic. To attempt to overcome this limitation, we have employed c...

journal_title：Journal of autoimmunity

authors： Smith CE,Miller SD

更新日期：2006-12-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction, and the secretion of TNF-alpha or IFN-gamma. The secretion of IFN-gamma can contribute to b...

journal_title：Journal of autoimmunity

authors： Barral AM,Thomas HE,Ling EM,Darwiche R,Rodrigo E,Christen U,Ejrnaes M,Wolfe T,Kay TW,von Herrath MG

更新日期：2006-11-01 00:00:00

abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

journal_title：Journal of autoimmunity

authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

更新日期：2006-11-01 00:00:00

abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

journal_title：Journal of autoimmunity

authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

更新日期：2006-08-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune rheumatic disease that targets salivary and lachrymal glands, characterized by a high concentration of serum autoantibodies directed against nuclear and cytoplasmic antigens. It is known that autoantibodies can enter viable cells and this phenomenon has functional consequences ...

journal_title：Journal of autoimmunity

authors： Sisto M,Lisi S,Castellana D,Scagliusi P,D'Amore M,Caprio S,Scagliusi A,Acquafredda A,Panaro MA,Mitolo V

更新日期：2006-08-01 00:00:00

abstract：:Congenital immune deficiency states have often been valuable experimental models of nature that have significantly enhanced our understanding of the immune response. The relationship between CD4+, CD25+ and Treg cells in the induction of autoimmunity has attracted significant attention. We report herein a male child o...

journal_title：Journal of autoimmunity

authors： Aoki CA,Roifman CM,Lian ZX,Bowlus CL,Norman GL,Shoenfeld Y,Mackay IR,Gershwin ME

更新日期：2006-08-01 00:00:00

abstract：:We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotoc...

journal_title：Journal of autoimmunity

authors： Khan NA,Yessoufou A,Kim M,Hichami A

更新日期：2006-06-01 00:00:00

abstract：:Glutamic acid decarboxylase 65 (GAD65) is a putative autoantigen associated with the pathogenesis of type 1 diabetes (T1D). The prevalence of autoreactive CD4+ T cells towards the immunodominant GAD65(555-567) epitope in DR4 healthy and T1D subjects was investigated with class II tetramers. A slightly higher percentag...

journal_title：Journal of autoimmunity

authors： Danke NA,Yang J,Greenbaum C,Kwok WW

更新日期：2005-12-01 00:00:00

abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

journal_title：Journal of autoimmunity

authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

更新日期：2005-09-01 00:00:00

abstract：:The complement component C4 is encoded by two genes: C4A and C4B on human chromosome 6p in the major histocompatibility complex (MHC). Most studies have linked the deficiencies in C4 with systemic lupus erythematosus (SLE) in Angio-Irish, North American, Black American, Mexican American, Australian and Japanese popula...

journal_title：Journal of autoimmunity

authors： Ittiprasert W,Kantachuvesiri S,Pavasuthipaisit K,Verasertniyom O,Chaomthum L,Totemchokchyakarn K,Kitiyanant Y

更新日期：2005-08-01 00:00:00

abstract：:Immunostimulatory CpG motifs can preferentially induce Th1 immune responses and have been applied to treat Th2-dominant disease. In this study, we investigated whether a plasmid with the addition of 20 copies of an immunostimulatory CpG motif (pB-CpG20) might prevent the development of scleroderma-like syndrome in tig...

journal_title：Journal of autoimmunity

authors： Shen Y,Ichino M,Nakazawa M,Ikejima T,Kojima Y,Okuda K,Minami M

更新日期：2005-05-01 00:00:00

abstract：:Autoantigen-specific TCR transgenic mice allow us to assess the role of T cells in autoimmunity. We have recently generated humanized TAZ10 transgenic mice expressing the human TCR specific for the immunodominant epitope of thyroid peroxidase (TPO). We have shown that these transgenic mice do not undergo tolerance in ...

journal_title：Journal of autoimmunity

authors： Badami E,Maiuri L,Quaratino S

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Evaluation of systematic epidemiological data regarding clinical characteristics, sex distribution and autoantibody pattern in Caucasian children with autoimmune hepatitis (AIH). STUDY DESIGN:Data of 142 children presenting with AIH (97 girls and 45 boys) have been analysed for their clinical, serological, a...

journal_title：Journal of autoimmunity

authors： Oettinger R,Brunnberg A,Gerner P,Wintermeyer P,Jenke A,Wirth S

更新日期：2005-02-01 00:00:00

abstract：:To characterize the humoral immune response to the protein tyrosine phosphatase (PTP)-like autoantigen (IA-2) in preclinical type 1 diabetes (T1D), and to assess the utility of epitope and isotype-specific IA-2 antibody responses as surrogate markers for disease development, we analyzed these antibodies in 34 initiall...

journal_title：Journal of autoimmunity

authors： Hoppu S,Härkönen T,Ronkainen MS,Akerblom HK,Knip M,Childhood Diabetes in Finland Study Group.

更新日期：2004-12-01 00:00:00

abstract：:IL-10 has been shown to be an important anti-inflammatory mediator that has both down-regulatory and immunomodulatory effects. Utilizing IL-10(-/-) mice we demonstrate the induction of low dose oral tolerance characterized by the up-regulation of TGF-beta and IL-4 and the suppression of Ag specific proliferation with ...

journal_title：Journal of autoimmunity

authors： Gonnella PA,Waldner HP,Kodali D,Weiner HL

更新日期：2004-11-01 00:00:00

abstract：:The features of autoantibodies (autoAb) to liver fumarylacetoacetate hydrolase (FAH) elicited in mice infected with mouse hepatitis virus (MHV) were studied by ELISA and western-blot competition assays. All sera tested contained Ab to cryptic FAH epitopes according with results from western-blot tests, whereas ELISA d...

journal_title：Journal of autoimmunity

authors： Mathieu PA,Gómez KA,Coutelier JP,Retegui LA

更新日期：2004-09-01 00:00:00

abstract：:The specific contributions of islet cell microenvironment during the development of autoimmune type 1 diabetes remain unclear. The aims of this study were to identify early immune-driven abnormalities in islets and pancreatic lymph nodes of NOD mice by cDNA arrays. We compared gene expression profiles of purified isle...

journal_title：Journal of autoimmunity

authors： Aspord C,Rome S,Thivolet C

更新日期：2004-08-01 00:00:00

abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

journal_title：Journal of autoimmunity

authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

更新日期：2004-06-01 00:00:00

abstract：:Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

journal_title：Journal of autoimmunity

authors： Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

更新日期：2004-06-01 00:00:00

abstract：:Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

journal_title：Journal of autoimmunity

authors： Kamei H

更新日期：2004-05-01 00:00:00

abstract：:Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) o...

journal_title：Journal of autoimmunity

authors： Wang X,Erf GF

更新日期：2004-02-01 00:00:00

abstract：:The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen ser...

journal_title：Journal of autoimmunity

authors： Bearzatto M,Lampasona V,Belloni C,Bonifacio E

更新日期：2003-12-01 00:00:00

abstract：:Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules in the B7 superfamily. Inducible costimulator (ICOS), the receptor for B7h (also known as B7RP-1), is expressed on T cells after T cell activation. Recently, using ICOS-def...

journal_title：Journal of autoimmunity

authors： Dong C,Nurieva RI

更新日期：2003-11-01 00:00:00

abstract：:Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We...

journal_title：Journal of autoimmunity

authors： Alarcón-Riquelme ME,Prokunina L

更新日期：2003-09-01 00:00:00